Captain Liam Hogan, fellow defender Jack Baldwin, midfielder Richie Towell and goalkeeper Chris Neal, all of whom have been on the sidelines, are unlikely to be in contention.
New signing Craig Conway made his debut against Walsall last week and is expected to keep his place.
The Ammies’ 3-0 win at Walsall was their first away victory in the English Football League.
Cambridge are set to be without forward Jabo Ibehre for a considerable period after he underwent a knee operation.
Gary Deegan (blood poisoning) also remains out, and it is anticipated the game will be too soon for Dan Jones (broken foot) to make his comeback.
Samir Carruthers (hamstring) is expected to be sidelined for a sixth successive match and Liam O’Neil (back/pelvis) remains a doubt, but Luke Hannant, after feeling a slight hamstring issue in last Saturday’s 2-2 draw with Macclesfield, is poised to return.
Reggie Lambe and Jack Roles will be unavailable due to international duty with Bermuda and Cyprus respectively.